منابع مشابه
Current status of vaccines for schistosomiasis.
Schistosomiasis, caused by trematode blood flukes of the genus Schistosoma, is recognized as the most important human helminth infection in terms of morbidity and mortality. Infection follows direct contact with freshwater harboring free-swimming larval (cercaria) forms of the parasite. Despite the existence of the highly effective antischistosome drug praziquantel (PZQ), schistosomiasis is spr...
متن کاملCysteine Peptidases as Schistosomiasis Vaccines with Inbuilt Adjuvanticity
Schistosomiasis is caused by several worm species of the genus Schistosoma and afflicts up to 600 million people in 74 tropical and sub-tropical countries in the developing world. Present disease control depends on treatment with the only available drug praziquantel. No vaccine exists despite the intense search for molecular candidates and adjuvant formulations over the last three decades. Cyst...
متن کاملQuantitative assessment of the impact of partially protective anti-schistosomiasis vaccines
BACKGROUND Mass drug administration (MDA) of praziquantel has been the intervention of choice against schistosomiasis but with limited success in interrupting the transmission. The development of anti-Schistosoma vaccines is underway. Our objective is to quantify the population-level impact of anti-Schistosoma vaccines when administered alone and in combination with mass drug administration (MD...
متن کاملTrick or Treat: The Role of Vaccines in Integrated Schistosomiasis Control
Recent systematic reviews [1,2] indicate that the geographic extent and burden of schistosomiasis exceeds official estimates. The risk for infection is particularly pronounced in sub-Saharan Africa, but also exists in many parts of South America, the Middle East, and Southeast Asia. Collectively, close to 800 million individuals are at risk of schistosomiasis, and over 200 million people are in...
متن کاملProtective Potential of Antioxidant Enzymes as Vaccines for Schistosomiasis in a Non-Human Primate Model
Schistosomiasis remains a major cause of morbidity in the world. The challenge today is not so much in the clinical management of individual patients, but rather in population-based control of transmission in endemic areas. Despite recent large-scale efforts, such as integrated control programs aimed at limiting schistosomiasis by improving education and sanitation, molluscicide treatment progr...
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ژورنال
عنوان ژورنال: Human Vaccines
سال: 2011
ISSN: 1554-8600,1554-8619
DOI: 10.4161/hv.7.11.17017